Tissue stimulators have recently become a hit among office procedures, especially tissue stimulators that contain polynucleotides.

What are polynucleotides? What is this?

Polynucleotides are fragments of DNA and RNA nucleic acids, they are present in all organisms. Used in aesthetic medicine, they are responsible for the healthy appearance of the skin and its elasticity. Polynucleotides combine a large amount of water molecules, thanks to which they increase skin hydration, they also affect the increase in the number and activity of fibroblasts - cells that are responsible for the structure of the skin. Polynucleotides contained, for example, in the preparation Nucleofill Strong fight free radicals and inhibit photoaging. Polynucleotides perfectly regenerate the skin after holidays, excessive radiation and acne scars.

Research conducted on polynucleotides:

The conducted research suggests that the skin-reactivating properties of polynucleotides may be stronger than those of other basic skin active ingredients, e.g. hyaluronic acid. The studies described so far show that pore size and skin thickness improved significantly in people in their 30s, while skin tone, wrinkles and sagging improved significantly in people in their 40s. No serious side effects have been observed.

Just one treatment results in excellent and visible results!

Action of polynucleotides:

Currently, each of us wants to look young and does not want to age, so aesthetic medicine must constantly develop. Patients care about immediate effects without side effects and treatments that are minimally invasive. Minimally invasive treatments allow patients to quickly return to normal social life, to practice sports and enjoy life.

Skin biorevitalization is undoubtedly one of these types of treatments. Tissue stimulators are not only anti-aging therapy, but also prepare the skin for other more invasive aesthetic medicine treatments. The current trend in aesthetic medicine is towards healthy skin and a natural look. We don't want to look exaggerated. Such effects can be obtained using preparations with polynucleotides, they are extremely effective and safe. Applied in injections, they rejuvenate the skin, instantly moisturizing and lifting it. Preparations containing polynucleotides act as short-term temporary fillers due to the viscoelasticity of long DNA fragments.

Polynucleotides are a great ingredient not only for aging skin. Thanks to their properties, they will prove themselves in the correction of deep scars, e.g. acne scars, post-traumatic scars and in the case of white stretch marks.

General indications for the procedure using polynucleotides are:

  1. anti-aging therapies
  2. anti-aging therapies combined with the use of chemical peels and lasers
  3. The need for rapid skin regeneration
  4. lack of hydration
  5. scars and stretch marks
  6. skin photodamage


The areas of the skin that can be biorevitalized are most often the face, neck, cleavage and hands - this is where you can see the passage of time.

When to perform treatments with polynucleotides?

Treatments with products that contain polynucleotides can be performed all year round. It is recommended to perform this type of treatment after the holidays to nourish and moisturize the skin.


What is the difference between treatments using tissue stimulators and needle mesotherapy?

Both of these treatments consist of skin injection. Treatments using tissue stimulators are performed at the application points specified by the product manufacturer, thanks to which few punctures are made, and the patient can return to social life immediately after the procedure, without fear that something will be visible. Needle mesotherapy consists in continuous puncturing of the skin and subjecting it to a larger area for the treatment, which increases the risk of breaking the capillaries and bruises after administration of the preparation, and thus extends the healing period of the skin after the procedure.


Tissue stimulators with polynucleotides available in Puremed:

Nucleofill Strong

Dives Med Polyfill