Ejal 40 1x2ml

What is Ejal 40 and how does it work?

Ejal 40 is a next-generation biorevitalisation preparation by Italian company Medixa srl. Unlike cross-linked HA fillers, Ejal 40 contains pure non-crosslinked hyaluronic acid with no additives or chemical enhancers — fully safe and biodegradable. Its action focuses on the deep rebuilding of the extracellular matrix (ECM) — the structural foundation of the dermis.

HA MMW – why does molecular weight matter?

Ejal 40 contains HA at medium molecular weight (MMW): 1200–1800 kDa — a biologically optimal parameter:

• LMW (low molecular weight) — small HA fragments act mainly pro-inflammatory and do not effectively rebuild ECM.
• MMW 1200–1800 kDa — the optimum: small enough to penetrate deeper dermal layers after injection, large enough to bind water and rebuild ECM space around fibroblasts, collagen and elastin.
• HMW (high molecular weight) — large HA molecules bind abundant water (filler effect) but penetrate less deeply and stimulate fibroblasts less effectively.

MMW HA at 40 mg/2 ml (= 20 mg/ml) creates the optimal environment for newly forming skin building blocks and increases the natural ability of fibroblasts to produce collagen — without externally introduced proteins.

ECM rebuilding – why this is more than hydration

The extracellular matrix (ECM) is a network of proteins and polysaccharides (collagen, elastin, HA, fibronectin) filling the space between dermal cells. With age ECM degrades — skin loses density, elasticity and regenerative capacity. Ejal 40 rebuilds this structure from the ground up: it delivers optimal MMW HA that occupies the correct ECM position, binds water and signals fibroblasts via CD44 receptors to resume collagen and elastin synthesis. This is complete tissue biorevitalisation — not just surface hydration.

4 BRP technique – a revolution in application precision

4 BRP (4 BioRevitalizationPoints) is the innovative Ejal 40 injection technique that sets it apart from classic multipuncture preparations:

• reduces injection points to just 4 anatomical distribution points per treatment area,
• minimises risk of post-injection swelling,
• significantly reduces procedural discomfort,
• while maintaining optimal tissue distribution of the preparation.

The BRP technique is particularly valued in patients with low pain tolerance and in delicate areas such as the neck and décolletage.

Treatment results

• lifting and improved skin firmness,
• smoothing of wrinkles and dehydration lines,
• improved skin density and structure,
• improved facial volumetry and oval restoration,
• reduction of connective tissue laxity,
• improved hydration and elasticity,
• natural stimulation of collagen synthesis by fibroblasts,
• revitalisation of UV- and environment-damaged skin.

Indications

• lax, dehydrated, dry skin,
• skin exposed to UV radiation and air conditioning,
• skin with pigmentation changes,
• stretch marks and scars,
• loss of facial density and volumetry,
• lifting and facial oval improvement — prevention and correction.

Treatment protocol

• Technique: 4 BRP (BioRevitalizationPoints) or classic intradermal multipuncture per specialist's protocol.
• Yield: 1 prefilled syringe 2 ml covers 2 treatment areas.
• Cycle: 3–4 sessions every 3–4 weeks, maintenance sessions every 4–6 months (per specialist's recommendations).

Composition and package contents

• Non-crosslinked HA MMW: 40 mg/2 ml (20 mg/ml), molecular weight 1200–1800 kDa
• Pure HA — no additives or chemical enhancers
• Contents: 1 × prefilled syringe 2 ml
• EAN: 9667966428630
• Manufacturer: Medixa srl, Via Figliola 57, 80040 San Sebastiano al Vesuvio, Italy

Treatment areas

Face, neck, décolletage, hands.

Contraindications

• pregnancy and breastfeeding,
• active infection or skin inflammation at the injection site,
• hypersensitivity to hyaluronic acid or any component,
• blood coagulation disorders,
• autoimmune diseases.

FAQ – questions and answers

What is HA MMW and why is it key in Ejal 40?

MMW (Medium Molecular Weight) means hyaluronic acid with a molecular weight of 1200–1800 kDa. This is the biologically optimal range: the molecule is small enough to deeply penetrate the dermis after injection, yet large enough to bind water and rebuild ECM. It activates fibroblasts via CD44 receptors to produce new collagen — LMW HA acts mainly pro-inflammatory, while HMW HA is more superficial. Ejal 40 uses the middle, biologically optimal molecular weight window.

How many treatment areas does one Ejal 40 2 ml syringe cover?

One 2 ml prefilled syringe contains 40 mg of HA — the optimal amount for a complete treatment of 2 areas (e.g. face + neck, or face + décolletage). This is a significant advantage over 1 ml products which typically cover only 1 area.

What is the 4 BRP technique and how does it differ from classic multipuncture?

The 4 BRP (4 BioRevitalizationPoints) technique involves delivering the full dose at just 4 anatomically defined points per treatment area — instead of the dozens of injections typical of classic multipuncture. The result is minimised post-injection swelling, significantly reduced pain, and full therapeutic efficacy maintained, as the preparation diffuses through the tissue from these distribution points.

How does Ejal 40 differ from a cross-linked HA filler?

Cross-linked HA fillers (for lip augmentation, deep wrinkle correction) act mechanically — their purpose is volumisation and contour correction. Ejal 40 contains pure non-crosslinked HA with no chemical modifiers — its goal is biological ECM rebuilding: improved density, hydration, elasticity and stimulation of endogenous collagen. It is a skin quality treatment, not a contouring one.

Why is Ejal 40 particularly recommended for UV- and air conditioning-exposed skin?

UV radiation and air conditioning are two main external factors that accelerate HA and collagen degradation in the dermis. UV stimulates free radicals and activates matrix metalloproteinases (MMPs) that break down ECM. Air conditioning accelerates water evaporation from the tissue. Ejal 40 replenishes lost HA at ECM level, restores hydration in the deeper skin layers and reactivates fibroblasts — reversing the degradation caused by these factors.

Ejal 40 is intended exclusively for use by doctors and cosmetologists trained in aesthetic medicine holding qualifications to perform injections. By purchasing this product you confirm that you hold the required professional qualifications.

• What is Ejal 40 and how does it work?
• HA MMW – why does molecular weight matter?
• ECM rebuilding – more than hydration
• 4 BRP technique – precision application
• Treatment results
• Indications
• Treatment protocol
• Composition and package contents
• Contraindications
• FAQ – questions and answers