Mastelli Newest 1x2ml

What is Mastelli Newest and who is it for?

Mastelli Newest is a regenerative needle mesotherapy preparation based on the patented PN-HPT® (Polynucleotides Highly Purified Technology). Unlike Plinest (classic biorevitalisation) or Plinest One (biostimulation and collagen), Newest focuses on supporting and repairing weakened skin — tired by daily stress, dehydrated, showing early to moderate signs of ageing, or requiring recovery after aesthetic treatments.

PN-HPT® polynucleotides target the skin's natural repair mechanisms:

• Repair process stimulation — activation of endogenous skin regeneration mechanisms,
• Skin structure improvement — extracellular matrix restoration and firmness improvement,
• Deep hydration — restoration of optimal moisture in tired and dehydrated skin,
• Complexion improvement — evening and brightening of a dull, grey complexion,
• Combined therapy support — ideal complement to comprehensive anti-ageing protocols.

The Mastelli Plinest range – formula orientation

Indications and treatment areas

• Skin laxity — restoring firmness and structure,
• Tired and dehydrated skin — deep regeneration and hydration,
• Early and moderate signs of ageing — correction and slowing,
• Skin requiring regeneration — repair process support,
• Combined therapy — complement to comprehensive anti-ageing protocols.

Treatment areas: face · neck · décolletage · hands

Treatment protocol

• Series: 3–4 sessions every 2–3 weeks,
• Results: noticeable after completing the full therapy,
• Route: intradermal injections.

Composition and package contents

• Active substance: Polynucleotides PN-HPT®
• Contents: 1 × prefilled syringe 2 ml
• EAN: 8053303261366
• Manufacturer: Mastelli S.r.l., Via Armea 90, 18038 Sanremo, Italy

FAQ – questions and answers

How does Mastelli Newest differ from Plinest?

Newest focuses on repair and regeneration of weakened skin — tired, dehydrated, with early to moderate signs of ageing. It also acts as support in combined therapies. Plinest 1×2 ml is classic PN-HPT® 20 mg/ml biorevitalisation — for revitalisation, anti-ageing and photo-ageing. Both are based on Mastelli's PN-HPT® technology and differ in clinical application profile.

Can Newest be combined with other treatments?

Yes — the manufacturer specifically notes that Newest acts as a support preparation in combined therapies. It complements protocols including HA, botulinum toxin or collagen-stimulating treatments — reinforcing and prolonging their effects by repairing the skin barrier and activating regenerative processes.

Mastelli Newest is intended exclusively for use by doctors and cosmetologists trained in aesthetic medicine holding qualifications to perform intradermal injections. By purchasing this product you confirm that you hold the required professional qualifications.

• What is Mastelli Newest and who is it for?
• The Mastelli Plinest range – formula orientation
• Indications and treatment areas
• Treatment protocol
• Composition and package contents
• FAQ