Refine+ Filler form 1x10 ml

Refine+ Forma Filler 1×10 ml – non-surgical body contouring, heavily cross-linked HA 20 mg/ml

Advanced next-generation body filler by ReNova Medical SRL (Prato, Italy) based on heavily cross-linked hyaluronic acid 20 mg/ml in a 1×10 ml presentation. CE Class III medical device (MDR 2017/745), produced in a GMP environment from 100% Italian, non-animal HA. Designed for non-surgical volumisation and contouring of large body areas: buttocks, hips, calves, thighs, knees and hands. Subcutaneous application with 18–21G×70mm cannula. Immediate, natural-looking results lasting up to 12 months. Guaranteed complete resorption, zero granuloma risk.

What is Refine+ Forma Filler and what sets it apart?

Refine+ Forma Filler is the flagship preparation of the Refine+ by ReNova Medical aesthetic system — science-based, skin-focused and patient-centred. Unlike classic facial fillers (1 ml), Forma Filler provides a 10 ml volume with rheological parameters (G'/G'' — very high elasticity and viscosity) specifically optimised for large body areas with thick, mechanically loaded subcutaneous tissue.

The preparation's dense gel structure remains anatomically stable after application — it does not migrate or deform under tissue movement and pressure. Volumisation is immediately visible after treatment, develops over several days and is maintained for up to 12 months through gradual, controlled biodegradation.

Heavily cross-linked HA 20 mg/ml – why these parameters matter

Refine+ Forma's rheological parameters place it in the highest category of body volumisers:

• G' (elasticity): very high — the gel maintains its shape under mechanical loading; does not compress or flatten during movement,
• G'' (viscosity): very high — the gel is dense and cohesive; cannula delivery is precise and material remains at the injection site,
• Cross-linking: heavily cross-linked — long-term volume and shape maintenance compared to lightly cross-linked revitalisation preparations,
• Endotoxins: <0.2 EU/mL — exceptional chemical purity minimising the risk of inflammation and nodule formation in sensitive patients.

Product profile – key clinical advantages

• 100% Italian-manufactured HA — GMP production, ISO 11737-2, EP 2.6.14/USP <85>, GC-MS analysis, full batch traceability,
• Very high viscosity and elasticity — stable volumising in large areas without risk of migration or deformation,
• Optimised for large body areas — buttocks, calves, upper arms, thighs, subcutaneous irregularities,
• 10 ml high-capacity presentation — efficient body contouring with fewer syringes and fewer injection points,
• Visible lifting and firming — enhanced tissue tension and improved skin appearance through volumetric structural support,
• Immediate, natural-looking results — volumising effect visible instantly without unnatural overcorrection,
• Minimal downtime — non-surgical, quick return to normal activities,
• Up to 12 months duration — dense gel structure allows gradual, stable biodegradation,
• 18G–21G cannula compatible — safe subdermal delivery across large areas with fan technique and low-trauma injection,
• Guaranteed complete resorption — zero risk of granuloma formation post-treatment.

Indications and treatment areas

• Buttocks: volume augmentation, shape correction, improved projection and firmness,
• Hips: contour harmonisation and body proportion improvement,
• Calves: profile balancing, asymmetry correction,
• Thighs/legs: skin firmness improvement, volume support,
• Knees: volume restoration, skin tension improvement,
• Hands: volume restoration and youthful appearance,
• General: non-surgical body contouring and definition, volumising and firming sagging skin in larger anatomical areas, elimination of tissue deficits including atrophy and polypoid irregularities.

Technical specifications and composition

• HA Concentration: 20 mg/ml
• Cross-linking: heavily cross-linked
• Elasticity (G'): very high
• Viscosity (G''): very high
• Injection depth: subcutaneous
• Application technique: cannula 18–21G × 70mm
• Endotoxins: <0.2 EU/mL
• Sterile, non-pyrogenic, biocompatible
• HA source: non-animal stabilised hyaluronic acid
• Contents: 1 × syringe 10 ml
• Recommended cannula: 18–21G × 70mm
• Classification: CE Class III medical device (MDR 2017/745)
• Quality standards: ISO 11737-2, EP 2.6.14/USP <85>, GC-MS, GMP environment
• Manufacturer: ReNova Medical SRL, Via del Molinuzzo 83, 59100 Prato, Italy
• Duration of results: up to 12 months

Contraindications

• pregnancy and breastfeeding,
• active infections or skin inflammation at the injection site,
• hypersensitivity to hyaluronic acid or any component,
• blood coagulation disorders,
• active autoimmune diseases,
• tendency to keloid scarring.

FAQ – questions and answers

How does Refine+ Forma Filler differ from classic facial HA fillers?

Classic facial fillers (1 ml) are designed for delicate facial anatomy with moderate or low G'/G''. Refine+ Forma contains 10 ml of heavily cross-linked HA with very high elasticity and viscosity — parameters essential for stable volumisation of large body areas (buttocks, thighs, calves) where tissue is thicker and subject to constant mechanical pressure. Forma is delivered via cannula 18–21G in the subcutaneous layer, not intradermally.

How long do the results last?

Results from Refine+ Forma Filler last up to 12 months. The dense, heavily cross-linked HA gel structure undergoes gradual, stable biodegradation — meaning volume reduces slowly and evenly without abrupt loss of effect. After degradation is complete, the preparation undergoes complete resorption with no residual material.

Why a 10 ml presentation instead of the standard 1 ml?

Contouring of large body areas (buttocks, calves, hips) requires significantly larger volumes than facial wrinkle correction. 10 ml in a single syringe enables efficient treatment of the entire target area with fewer cannula passes — resulting in less tissue trauma, shorter procedure time and more homogeneous material distribution.

Is there a risk of migration or nodule formation?

Migration risk is minimal thanks to the very high elasticity (G') and cohesion of the gel — the material remains anatomically stable at the injection site under tissue mechanical stresses. Endotoxins <0.2 EU/mL ensure exceptional purity, minimising inflammation and nodule risk. The manufacturer confirms zero risk of granuloma formation post-treatment.

Is there significant downtime after the procedure?

No — thanks to cannula technique (18–21G × 70mm) rather than needles, the procedure is minimally traumatic and significantly reduces bruising risk. This is a non-surgical procedure with minimal downtime — patients typically return to normal activities the same or following day.

Refine+ Forma Filler is a Class III medical device intended exclusively for use by doctors and specialists trained in aesthetic medicine holding qualifications to perform subcutaneous cannula injections. By purchasing this product you confirm that you hold the required professional qualifications.

• What is Refine+ Forma Filler and what sets it apart?
• Heavily cross-linked HA 20 mg/ml – why it matters
• Product profile – key clinical advantages
• Indications and treatment areas
• Technical specifications
• Contraindications
• FAQ – questions and answers