MD-Tissue - Collagen (10x2ml)

This is the single-ampoule 1×2 ml version. For regular treatment protocols (8–10 sessions), save with MD-TISSUE 10×2 ml — lower unit price and free delivery. For cellulite and scarring: MD-MATRIX 1×2 ml.

What is MD-TISSUE and how does tropocollagen work?

MD-TISSUE is a GUNA collagen medical device focused on anti-ageing, wrinkle reduction and photo-ageing. Tropocollagen (native, non-cross-linked animal collagen) is the direct precursor of skin collagen — as a collagen monomer it can penetrate tissue after intradermal injection and be directly utilised by fibroblasts for new collagen synthesis.

• Tropocollagen — hydrates mature skin, restores elasticity, provides substrate for new collagen fibre synthesis,
• Vitamin C — essential cofactor for collagen hydroxylation,
• Magnesium gluconate — supports protein synthesis enzymes,
• Vitamins B1, B2, B6 — cellular metabolism and fibroblast regeneration.

MD-TISSUE vs MD-MATRIX – which to choose?

Indications and treatment

• Wrinkle correction — tissue remodelling and wrinkle smoothing,
• Photo-ageing reduction,
• Anti-ageing,
• Skin firming,
• used alone or alongside HA, botulinum toxin and other preparations.

Injection techniques and treatment protocol

Intradermal: disinfect → depth 1–3 mm → 0.2–0.3 ml per puncture.

Tunnelling: 0.3 ml per wrinkle, insert full needle length, deliver while withdrawing.

Protocol: first 2 weeks: 2×/week → then 1×/week (avg 8–10 sessions) → maintenance 1×/week for 10 weeks → chronic changes: 1×/week for 1 month, then 1×/month.

Composition and package contents

• Active substance: tropocollagen (animal collagen)
• Excipients: vitamin C (ascorbic acid), magnesium gluconate, vitamin B6 (pyridoxine HCl), vitamin B2 (riboflavin), vitamin B1 (thiamine HCl)
• Contents: 1 × 2 ml ampoule
• EAN: 8033875149187
• Manufacturer: GUNA Medical Device, Via Palmanova 71, 20132 Milan, Italy

Clinic pack with free delivery: MD-TISSUE 10×2 ml.

FAQ – questions and answers

When to choose 1×2 ml vs 10×2 ml?

The 1×2 ml version (this product, 52 PLN) is ideal for trialling the preparation, topping up by a single ampoule, or low-volume clinics. The 10×2 ml pack offers a lower unit price plus free delivery — optimal for clinics running full treatment cycles (8–10 sessions per patient). Composition and action are identical.

How does the tunnelling technique for wrinkle correction work?

The tunnelling technique involves inserting the needle to its full length along the wrinkle (beneath it) and then delivering 0.3 ml of product while slowly withdrawing the needle. Tropocollagen is deposited along the entire wrinkle, enabling uniform tissue remodelling and precise smoothing.

MD-TISSUE is intended exclusively for use by doctors and cosmetologists trained in aesthetic medicine holding qualifications to perform intradermal injections. Full instructions available as PDF on the product page. By purchasing you confirm required professional qualifications.

• What is MD-TISSUE and how does tropocollagen work?
• MD-TISSUE vs MD-MATRIX
• Indications and treatment
• Injection techniques and protocol
• Composition and package contents
• FAQ