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Newest One 5×4 ml — clinic pack for full series (5 × 4 ml). Single version: Newest 1×2 ml. Biostimulation with lifting: Plinest One 5×4 ml.

What is Mastelli Newest One and what makes the 5×4 ml clinic pack special?

Mastelli Newest One is an extended-action regenerative treatment for intensive reconstruction of ageing and weakened skin. The 5 × 4 ml glass ampoule clinic pack enables full treatment series covering large areas or multi-session therapeutic cycles.

PN-HPT® polynucleotides in Newest One act in multiple directions:

• Accelerated cellular regeneration — activation of endogenous repair mechanisms,
• ECM reconstruction — support for collagen, elastin and glycosaminoglycan synthesis,
• Elasticity and density improvement — restoration of skin's mechanical properties,
• Intensive hydration — improved tissue moisture retention,
• Skin tone evening and radiance restoration.

The Mastelli range – clinic-pack formula orientation

Indications and treatment areas

• Ageing, lax skin — intensive reconstruction and firmness restoration,
• Loss of elasticity and density — collagen matrix regeneration,
• Pigmentation and loss of radiance — skin tone evening and brightening,
• Post-aesthetic-treatment skin — barrier rebuilding and recovery support,
• used independently or as part of a combined protocol.

Treatment areas: face · neck · décolletage · hands

Treatment protocol

• Series: 3–4 sessions every 2–3 weeks,
• Results: visible after completing the full therapy,
• Volume per session: 4 ml per session,
• Route: intradermal injections.

Composition and package contents

• Active substance: Polynucleotides PN-HPT®
• Contents: 5 × glass ampoule 4 ml
• EAN: 8053303261410
• Manufacturer: Mastelli S.r.l., Via Armea 90, 18038 Sanremo, Italy

FAQ – questions and answers

How does Newest One differ from Plinest One?

Both are 5×4 ml clinic packs based on PN-HPT® technology. Newest One focuses on deep biostimulation and ECM reconstruction for ageing skin — elasticity, density, pigmentation and post-treatment recovery. Plinest One concentrates on biostimulation, collagen production, skin tone and lifting. The choice depends on the patient's dominant need.

What does ECM reconstruction mean?

The extracellular matrix is the network of proteins and polysaccharides (collagen, elastin, hyaluronic acid, fibronectin) surrounding skin cells, responsible for elasticity, firmness and hydration. Ageing degrades ECM — skin loses density, elasticity and moisture capacity. PN-HPT® polynucleotides stimulate fibroblasts to rebuild and synthesise ECM components, restoring skin structure from its foundations.

Mastelli Newest One is intended exclusively for use by doctors and cosmetologists trained in aesthetic medicine holding qualifications to perform intradermal injections. By purchasing you confirm the required professional qualifications.

• What is Mastelli Newest One and what makes the 5×4 ml clinic pack special?
• The Mastelli range – clinic-pack formula orientation
• Indications and treatment areas
• Treatment protocol
• Composition and package contents
• FAQ