Neauvia Stimulate(1x1ml)

Unique combination of volumetric filling and collagen biostimulation in one preparation. HA cross-linked with PEG (not BDDE) — superior safety. CaHA evenly distributed — no migration risk. Clinically confirmed results.

Three active ingredients – synergy of filling and biostimulation

HA 26 mg/ml in PEG/IPN technology – safe and stable volumetric filling

Hyaluronic acid at 26 mg/ml sourced from Bacillus subtilis (Neauvia Organic) is cross-linked using PEG polymer instead of the standard BDDE used in most fillers. The IPN (Interpenetrating Polymer Network) technology creates a stable, three-dimensional gel network that provides volume and shape to tissues with immediate wrinkle and furrow correction.

CaHA 1% (Calcium Hydroxyapatite) – long-term collagen stimulation

Calcium Hydroxyapatite (CaHA) at 1% is a biodegradable collagen biostimulator — initiating fibroblast signalling pathways leading to new collagen fibre synthesis. In Neauvia Stimulate, CaHA microspheres are evenly distributed throughout the IPN hydrogel, completely preventing migration and ensuring uniform biostimulation across the treatment area. The neocollagenesis effect persists long after filler degradation.

Amino acids: glycine and L-proline – collagen building blocks

Glycine and L-proline are the two key amino acids comprising the collagen polypeptide chain. Their direct delivery into the dermis supports fibroblasts in endogenous collagen synthesis — complementing and amplifying the CaHA biostimulatory effect.

Indications, benefits and product details

Indications:

• Deep skin depressions — deep wrinkles and nasolabial folds,
• Skin stimulation and revitalisation.

Benefits:

• Unique combination of filling and biostimulation in one preparation,
• Significant improvement in skin density,
• Results confirmed by clinical studies,
• Superior safety: PEG instead of BDDE + HA from Bacillus subtilis,
• Slow biodegradation and long-lasting result.

Product details

• Kit: 1 × pre-filled syringe 1 ml + 1 × 22G × 2" cannula + 1 × 21G × 1" needle
• EAN: 8053736080008
• Manufacturer: MATEXLAB, Via Carlo Urbani, 2, 72100 Brindisi, Italy

FAQ – questions and answers

How does PEG cross-linking differ from standard BDDE in HA fillers?

BDDE (1,4-butanediol diglycidyl ether) is the most commonly used cross-linking agent in traditional HA fillers — residual amounts remain in the finished product. PEG (polyethylene glycol) used by Neauvia in IPN technology is a polymer with a well-documented biomedical safety profile, widely used in implants, surgical sutures and drug carriers. PEG cross-linking eliminates residual BDDE, offering high biocompatibility while maintaining gel stability. The IPN technology creates a more homogeneous gel structure with uniform CaHA distribution.

How does Neauvia Stimulate differ from Neauvia Hydro Deluxe?

Neauvia Stimulate — cross-linked HA 26 mg/ml (PEG/IPN) + CaHA 1% + amino acids; tissue stimulator with deep wrinkle/furrow filling and long-term collagen biostimulation. Applied with cannula or needle. Neauvia Hydro Deluxe — non-cross-linked HA 18 mg/ml + CaHA 0.01% + amino acids; biorevitalisation booster for needle mesotherapy delivering superficial hydration and mild biostimulation. Stimulate acts deeper and longer; Hydro Deluxe is gentler and hydrating.

Neauvia Stimulate is intended exclusively for use by doctors and cosmetologists trained in aesthetic medicine holding qualifications to perform injections. By purchasing, you confirm the required professional qualifications.

• Three active ingredients – synergy of filling and biostimulation
• Indications, benefits and product details
• FAQ