Nithya Synerlift DMAE & PDRN 5 × 5 ml

Official and exclusive distribution in Poland

PureMED is the sole authorised distributor of the Nithya brand (Euroresearch Srl) in Poland.

No other shop or wholesaler in Poland is authorised to sell Nithya products. By purchasing from PureMED you are guaranteed product authenticity with full batch and expiry-date traceability.

This is the clinic pack 5×5 ml (full 5-session cycle). If you want to test the product or need a single vial, the 1×5 ml version is also available.

• What is NITHYA Synerlift DMAE & PDRN?
• Dual-Firming Action – the synergistic effect of two substances
• DMAE – mechanism of firming action
• PDRN – mechanism of advanced skin renewal
• Hyaluronic acid – hydration and elasticity
• Treatment results
• Indications and treatment areas
• Treatment protocol
• Composition and package contents
• Contraindications
• Synergistic protocol with other Nithya products
• Offer for clinics and practices
• FAQ – questions and answers

What is NITHYA Synerlift DMAE & PDRN?

NITHYA Synerlift DMAE & PDRN is an advanced, ready-to-use mesotherapy cocktail produced by Euroresearch Srl — the same manufacturer behind the unique NITHYA Type I Collagen line. The product combines three key active substances: DMAE (dimethylaminoethanol), PDRN (polydeoxyribonucleotide) and hyaluronic acid, creating the Dual-Firming Action — a dual mechanism of simultaneous firming and deep regeneration of the skin.

Unlike classic mesotherapy products based solely on hyaluronic acid, Synerlift acts on three levels simultaneously: firms the cell membrane and muscle tone of the skin (DMAE), stimulates tissue regeneration and neoangiogenesis (PDRN), and restores hydration and elasticity (HA). Results are visible from the first treatment and build with each successive session.

Dual-Firming Action – the synergistic effect of two substances

The Dual-Firming Action concept is based on combining two substances that act on the skin through different, complementary pathways:

• DMAE acts quickly — from the very first treatment it firms cell membranes and improves skin muscle tone, delivering an immediate lifting effect.
• PDRN acts deeper and long-term — it stimulates adenosine A2A receptors, triggering tissue repair processes, collagen synthesis and the formation of new blood vessels (neoangiogenesis).

Together they create an effect neither substance could achieve alone: immediate skin firmness combined with progressive, long-term biological regeneration.

DMAE – mechanism of firming action

2-dimethylaminoethanol (DMAE) is an analogue of vitamin B-choline and a direct precursor of acetylcholine. In aesthetic medicine, DMAE acts in a multi-directional way:

• Strengthens cell membranes — increases structural integrity of membranes, translating into improved tone and turgor of skin cells.
• Improves muscle tone — as a precursor of acetylcholine it stimulates facial muscle contractions, producing a lifting effect without botulinum toxin.
• Anti-inflammatory action — documented anti-inflammatory activity, reducing inflammatory markers in the skin.
• Smooths expression wrinkles — particularly effective on forehead lines, crow's feet and lip lines.
• Improves lip shape and volume — through stimulation of the orbicularis oris muscle.

PDRN – mechanism of advanced skin renewal

Polydeoxyribonucleotide (PDRN) is a natural DNA derivative (50–1500 kDa) from salmon roe, with a clinically proven multi-directional mechanism:

• Activation of adenosine A2A receptors — regulate tissue repair, reduce inflammation and stimulate fibroblasts to synthesise collagen and elastin.
• Neoangiogenesis — promotes the formation of new blood vessels, improving microcirculation — skin appears more radiant, alive and better oxygenated.
• Collagen synthesis — stimulates intensive production of type I and III collagen.
• Increased skin thickness — clinical studies confirm PDRN measurably increases dermal thickness.
• Improved skin texture — smoothing of surface, reduction of pores.
• Support for repair processes — particularly valuable in mature and UV-damaged skin.

PDRN is the same active substance found in popular Korean PDRN skinboosters (e.g. Rejuran) — available here at a significantly more competitive price.

Explore more PDRN mesotherapy products: Polynucleotides at PureMED.

Hyaluronic acid – hydration and elasticity

HA plays a role that is complementary and enhancing to DMAE and PDRN. It provides deep intradermal hydration, improved skin elasticity and volume, and creates an optimal environment for regenerative processes. HA binds water up to ~1,000 times its weight — hence the immediate hydration and radiance after treatment.

Treatment results

• immediate skin firming and lifting (from the first treatment),
• reduction of forehead wrinkles, crow's feet and lip lines,
• improved lip shape and definition,
• improved facial muscle tone,
• deep cellular regeneration and tissue rebuilding,
• stimulation of collagen and elastin synthesis,
• improved microcirculation and neoangiogenesis,
• increased dermal thickness and density,
• intensive hydration and improved skin elasticity,
• brightening and evening of skin tone,
• reduction of photoageing and chronological ageing signs.

Indications and treatment areas

• lax skin lacking tone and elasticity,
• loss of radiance and skin luminosity,
• signs of photoageing and chronological ageing,
• expression wrinkles: forehead, crow's feet, lip lines,
• tired, dull, dehydrated skin,
• skin requiring regeneration after aesthetic treatments,
• complementing NITHYA Type I Collagen therapy (combined protocol).

Treatment areas: face, neck, décolletage.

Treatment protocol

• Standard cycle: 3–5 treatments at 2–3 week intervals (one 5×5 ml pack = complete 5-session cycle).
• Maintenance treatments: 1–2 times a year or as individually indicated.
• Ready to use: no preparation required — each 5 ml vial is ready for direct injection.
• Injection techniques: needle mesotherapy (nappage, picotage, linear) or microneedling (dermapen).
• The specific protocol should be tailored by the practitioner to the patient's skin condition and treatment goal.

Composition and package contents

• Active substances: DMAE (dimethylaminoethanol), PDRN (polydeoxyribonucleotide 50–1500 kDa), hyaluronic acid
• Form: ready-to-inject solution
• Contents: 5 × vial 5 ml
• Manufacturer: Euroresearch Srl, Corso Venezia 5, 20121 Milan, Italy
• Leaflet: Download PDF leaflet ↓

Also available as a single vial: NITHYA Synerlift 1×5 ml.

Contraindications

• pregnancy and breastfeeding,
• active skin infections and inflammation at the injection site,
• autoimmune diseases,
• hypersensitivity to any component of the product,
• blood clotting disorders or anticoagulant medication (medical consultation required).

Synergistic protocol with other Nithya products

NITHYA Synerlift DMAE & PDRN fits perfectly into comprehensive rejuvenation protocols built with the Nithya line:

• Synerlift + NITHYA Type I Collagen Face — deep collagen biostimulation (dermal layer) combined with DMAE+PDRN firming and regeneration. Synerlift used between collagen sessions as a maintenance treatment.
• Synerlift + NITHYA Extended Treatment Cream — post-treatment cream with PDRN extends the regeneration effects for patients between clinic visits.

Offer for clinics and practices – exclusive Nithya distributor in Poland

The 5×5 ml pack is the most popular choice for clinics running regular Synerlift programmes. As the sole authorised Nithya distributor in Poland we offer:

• Individual wholesale pricing — volume-based discounts negotiated individually.
• Nithya Partner Practice Programme — treatment protocols, educational materials and preferential purchasing terms.
• Expert support — guidance on building mesotherapy protocols for your practice.
• Fast Order — quick orders by phone: +48 734 614 040.

Contact: ph@puremed.com.pl or +48 734 614 040.

FAQ – questions and answers

Does the 5×5 ml pack give 5 full treatments for one patient?
Yes — one 5 ml vial covers one full facial treatment (or face + neck). The 5×5 ml pack is sufficient for a complete 5-session cycle for one patient, or individual treatments for several different patients.

How does Synerlift DMAE & PDRN differ from a classic HA skinbooster?
A classic skinbooster hydrates and fills intradermally but does not stimulate regeneration or firm the skin. Synerlift acts on three levels simultaneously: firms (DMAE), regenerates (PDRN) and hydrates (HA) — the effect is significantly broader and appears faster.

Is the PDRN in Synerlift the same substance as in Rejuran?
Yes — the same class of active substance, delivered in one ready-to-use mesotherapy product at a more competitive price.

When are the first results visible?
A firming and brightening effect is visible after the first treatment (DMAE acts immediately). The full PDRN regenerative effect develops gradually over several weeks following the cycle.

Can Synerlift be used alongside Nithya collagen mesotherapy?
Yes — the recommended combination. NITHYA Type I Collagen biostimulates the deep dermal layer; Synerlift is used as a superficial mesotherapy between sessions, maintaining the lifting and regenerative effect throughout the therapy.

Can Synerlift be used in microneedling (dermapen) mesotherapy?
Yes — suitable for both needle and microneedling mesotherapy. In dermapen applications it is applied as a serum on the skin during the procedure.

This product may only be used by doctors and cosmetologists trained in aesthetic medicine and holding qualifications to perform injections or mesotherapy procedures. By purchasing this product you confirm that you hold the required professional qualifications.