Radiesse 1x1,5 ml

What is Radiesse and how does it differ from HA fillers?

Radiesse is the only original tissue stimulator and filler based on Calcium Hydroxylapatite (CaHA) — a substance that naturally forms the structure of bones and teeth. FDA-approved and CE-certified, produced by Merz Aesthetics — a global aesthetic medicine leader since 1953.

Unlike hyaluronic acid fillers, Radiesse is not merely a "volume cushion" — it is an active biostimulator. CaHA microspheres injected into tissue become a scaffold around which the skin's own fibroblasts build new collagen and elastin fibres. When the carrier gel (CMC) biodegrades after ~3 months, the patient's own collagen remains — maintaining the effect for many further months.

Dual mechanism of action of Radiesse

Phase 1 – immediate (CMC gel matrix)

Immediately post-injection, the carboxymethylcellulose (CMC) gel matrix delivers an immediate volumetric effect: wrinkle correction, restoration of lost facial contour and volume. Results are visible from the moment of injection. After ~3 months the carrier gel biodegrades completely.

Phase 2 – long-term (CaHA biostimulation)

Calcium Hydroxylapatite (CaHA) microspheres remain in tissue as a scaffold stimulating fibroblasts. The skin's natural regeneration mechanism integrates new collagen fibres around the CaHA particles, which then themselves biodegrade. Newly produced collagen maintains skin density and volume for approximately 2 years — with the total effect of Radiesse lasting up to 35 months depending on the treatment area.

Calcium Hydroxylapatite – why is it such a unique ingredient?

CaHA is the natural building block of bones and teeth, containing phosphorus and calcium — the very same material as the human skeleton. Radiesse is the only aesthetic preparation with CaHA and confirmed clinical safety:

• no animal-derived substances — synthetic CaHA, structurally identical to natural,
• safe for allergy-prone patients — no allergy testing required before treatment,
• 100% biodegradable — complete breakdown without permanent residual deposits,
• FDA and CE approved — the highest global standard of clinical safety,
• extensive scientific evidence confirming efficacy and safety.

Indications and treatment areas

• Facial volumetry — restoring lost volume and contour,
• Lifting and skin densification,
• Nasolabial folds — deep and moderate,
• Marionette lines,
• Cheeks and cheekbones — volume and definition,
• Chin and jawline — contouring and projection,
• Non-surgical nose correction,
• Eyebrow lifting,
• Hand rejuvenation — volume restoration, reduced visibility of veins,
• Acne scars.

Treatment results

• immediate wrinkle and fold filling,
• restoration of lost facial contour and oval,
• improved volumetry — natural, non-artificial result,
• lifting and firmness restoration without overcorrection,
• long-term collagen and elastin stimulation,
• effects lasting up to 35 months,
• next treatment possible after approximately 24 months.

Protocol and application

• Technique: needle or cannula into designated deep/subcutaneous injection points.
• Results: visible immediately after treatment.
• Treatment: can be performed alone or combined with other aesthetic medicine procedures.
• Duration: up to 35 months depending on area, lifestyle, diet and activity.
• Next session: after approximately 24 months.

Composition and package contents

• Active substance: Calcium Hydroxylapatite (CaHA) — synthetic, no animal-derived substances
• Carrier: carboxymethylcellulose (CMC) gel matrix, water, glycerine
• Without lidocaine
• Contents: 1 × prefilled syringe 1.5 ml
• EAN: 4046222112189
• Manufacturer: Merz North America Inc., 4133 Courtney St., Suite 10, WI 53126 Franksville, USA
• EU Responsible Person: Merz Aesthetics GmbH, Eckenheimer Landstraße 100, 60318 Frankfurt am Main, Germany
• Approvals: CE 2004, FDA 2006

Contraindications

• pregnancy and breastfeeding,
• cold or other active infections,
• active allergy phase,
• inflammation at the treatment site (including herpes),
• autoimmune diseases,
• tendency to keloid scarring,
• anticoagulant medication,
• confirmed allergy to any component,
• oncological conditions,
• uncontrolled diabetes,
• permanent fillers in the treatment area.

FAQ – questions and answers

How does Radiesse differ from HA fillers?

HA fillers act primarily mechanically — filling and hydrating, with effects limited to gel duration (6–18 months). Radiesse is a biostimulator: CaHA microspheres activate fibroblasts to produce the patient's own collagen. When the carrier gel biodegrades, the effect is not lost — it is sustained by newly produced collagen lasting approximately 2 years. Radiesse improves skin quality, not just its shape.

Why is Radiesse safe for allergy-prone patients?

Calcium Hydroxylapatite is a substance identical to the natural building block of human bones and teeth. It does not originate from animal sources (e.g. bovine collagen) and contains no exotic chemical modifiers. Allergy risk is negligible — Radiesse requires no pre-treatment allergy testing, which is a distinguishing advantage among professional fillers.

What happens when the carrier gel is absorbed after 3 months?

This is one of the most common misconceptions about Radiesse: it does not mean the effect is lost. The CMC carrier matrix biodegrades after ~3 months — but by that time CaHA microspheres have induced the production of new collagen fibres that replace the gel as a volumising scaffold. The effect is then sustained by the patient's own collagen for a further ~2 years.

Why choose the version without lidocaine?

The lidocaine-free version is chosen by specialists who prefer independently selecting the anaesthetic approach (e.g. topical anaesthetic cream or regional block) or combining Radiesse with other procedures. The absence of lidocaine gives the specialist full control over the anaesthesia protocol.

Do Radiesse results look natural?

Yes — Radiesse fills and rejuvenates without overcorrection. CaHA after application integrates with tissue and gradually builds natural collagen rather than imitating it. Results look like appropriate rejuvenation, not an "inflated face" — a key advantage of biostimulatory preparations over pure HA fillers used in excess volumes.

Radiesse is intended exclusively for use by doctors and specialists trained in aesthetic medicine holding qualifications to perform deep and subcutaneous injections. By purchasing this product you confirm that you hold the required professional qualifications.

• What is Radiesse and how does it differ from HA fillers?
• Dual mechanism of action
• Calcium Hydroxylapatite – unique ingredient
• Indications and treatment areas
• Treatment results
• Protocol and application
• Composition and package contents
• Contraindications
• FAQ – questions and answers